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Major allergen

An allergenic protein that has been found to be clinically significant in over 50% of a population of patients allergic to that particular allergen.

Major allergen

s have been characterized for a number of allergenic species. Common examples of

Major allergen

s include: Amb a 1 (Ragweed), Fel d 1 (Cat), Phl p 5 (Timothy grass), etc.… read more 705357C1-B577-4332-A248-2D41FB183786Created with sketchtool.

Profilin & Pan-Allergens

Profilin & Pan-Allergens Cross-reactivity is often seen between unrelated species due to shared minor allergens such as Profilin. A minor allergen is an allergenic protein that has demonstrated clinical sensitivity in a minority of patients in a population. Common allergens that demonstrate clinical sensitivity across unrelated species are known as Pan-Allergens. Profilin is a structual… read more 705357C1-B577-4332-A248-2D41FB183786Created with sketchtool.

References

Home  >  References References General References Used Throughout Stability References Painful Injection From 50% Glycerin FDA Standardization

Major allergen

And Standardization Regional Relevance Of Allergens Cross-Reactivity Management Of Anaphylaxis Coring & Syringe Technique Skin Testing USP 797 References – Beyond Use Date, Pharmacy Compounding Rules Allergen Information General References Used Throughout Cox, L, et al.… read more 705357C1-B577-4332-A248-2D41FB183786Created with sketchtool.

Fel d 1

A

Major allergen

associated with cat allergy. Fel d 1 is highly correlated with cat-related allergy symptoms. This well-characterized protein is measured in each lot of manufactured cat extract, serving as the basis for cat extract standardization. The naming convention for allergens is to sequentially number the proteins following a shortened form of the Latin… read more 705357C1-B577-4332-A248-2D41FB183786Created with sketchtool.

Amb a 1

A

Major allergen

contained in short ragweed pollen. Short ragweed extracts are labeled with AgE concentrations (now called Amb a 1) The concentration of AgE (i.e., Amb a 1) is measured for each manufactured lot of extract, using a standardized assay. Clinical studies have been conducted, which established a therapeutic dose range for Ragweed allergy… read more 705357C1-B577-4332-A248-2D41FB183786Created with sketchtool.

Dosing

Dosing One of the primary objectives when mixing allergenic extracts is to prepare a patient’s treatment set in a way that ensures an optimal therapeutic dose of each allergen in the patient’s allergen extract vial. Therefore, the limiting step when mixing is deciding what volume of each allergen to add to a patient’s maintenance vial.… read more 705357C1-B577-4332-A248-2D41FB183786Created with sketchtool.

Oral Allergy Syndrome

Oral Allergy Syndrome Many common food allergens are cross-reactive with unrelated (or distantly related) pollen allergens, such as Apple with Birch, or Melon with Ragweed. This is because they share evolutionarily conserved protein structures that have a similar function across species. For example, the

Major allergen

, Bet v 1, found in Birch, is an essential… read more 705357C1-B577-4332-A248-2D41FB183786Created with sketchtool.

Standardized Extracts

Standardized Extracts The FDA has mandated standardization testing for a limited number of extracts. The purpose of standardization is to minimize the amount of variability between lots and manufacturers of the same extract. Extracts that have been standardized by the FDA include the northern pasture grasses (Timothy, June, Meadow Fescue, Orchard, Redtop, Perennial Rye, Sweet… read more 705357C1-B577-4332-A248-2D41FB183786Created with sketchtool.